As wide as is an adverb that describes the extent or degree to which something extends or expands. It is used to convey the idea that something is very broad or expansive, covering a large area or distance.
One common use of the phrase as wide as is to describe the width of something. For example, a person might say, "The river is as wide as a mile at this point," to convey that the river is very broad and covers a large distance. Similarly, someone might say, "The room was as wide as a football field," to convey that the room was very large and spacious.
As wide as can also be used to describe the scope or range of something. For example, someone might say, "The company's operations are as wide as the entire country," to convey that the company has a very large presence and does business in many different locations. Similarly, someone might say, "The impact of the disaster was as wide as the entire region," to convey that the disaster affected a large area and had far-reaching consequences.
In addition to its use in describing physical dimensions or scope, as wide as can also be used to describe the breadth or depth of something more abstract, such as knowledge or experience. For example, someone might say, "She has a knowledge base as wide as any expert in the field," to convey that the person has a very broad and deep understanding of a particular subject. Similarly, someone might say, "His experience in the industry is as wide as anyone's," to convey that the person has a very broad and diverse range of experience in a particular field.
Overall, the phrase as wide as is a useful way to describe the extent or degree to which something extends or expands, whether it be physical dimensions, scope, or more abstract qualities. It is a clear and concise way to convey the idea that something is very broad or expansive, covering a large area or distance.
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Whereas an antagonist is a drug that binds to the receptor either on the primary site, or on another site, which all together stops the receptor from producing a response. That may be a trade-off people are willing to make. Biosimilars have the potential to enhance treatment accessibility, and with biologic patents beginning to expire, this is an interesting era for the two treatment options. Marcia Angell, former editor in chief of The New England Journal of Medicine, points out that pharmaceuticals are the fastest rising segment of our national healthcare bill—and yet 75 percent of all new drugs coming to market are merely imitations of existing medications. What is a biosimilar agent? In cases like this, those trailing the leader hope to bring to market a new drug that can be a viable competitor to the original one.
What is a child without parents called? Analog or analogue drugs are those, which are chemically similar to other illegal or illicit narcotic drugs or substances, such as heroin. What is a biosimilar agent? NMEs have chemical structures that have never been approved before. NMEs have chemical structures that have never been approved before. In 2002, for example, pharmaceutical profits dropped only slightly, from 18. What is patent Evergreening? Yet drug companies spend billions marketing them. Is insulin still under patent? Biotech insulin is now the standard in the U.
This incremental innovation has led to some referring to me-toos as "me-betters". The most common arguments can be summarized as follows: me-too drugs offer an improvement on the efficacy of the prototype; they show a different profile of adverse effects; they are effective in patients resistant to the prototype; they improve compliance in long-term treatment; they are less expensive than the … What are first in class drugs? Because the amount of money drug companies invest in research and development is directly related to their annual sales. British Journal of Clinical Pharmacology. What is a novel drug? What class drug is best? Business Ethics of Innovation. What is patent Evergreening? What is a me too product? Patents for Development: Improved Patent Information Disclosure and Access for Incremental Innovation. Drug activity: A measure of the physiological response that a drug produces. As this paper shows and as has been the case in my own experience , what happens is that a new therapeutic idea becomes possible or plausible, and everyone takes off at roughly the same time.
The same sort of speed-up has taken place for third and later entries as well. He has written about pharmaceutical companies for New York Magazine, the Long Island Press, the Valley Advocate, the New Haven Advocate and the Progressive Populist. But one thing's for sure. Analog or analogue drugs are those, which are chemically similar to other illegal or illicit narcotic drugs or substances, such as heroin. Pharmacoevolution: the advantages of incremental innovation PDF.
Even drugs used for the same sorts of treatment differ chemically. An Introduction to Medicinal Chemistry. Research in Social and Administrative Pharmacy. You can order the 76-page special Pharmaceuticals Report from Wall Street Transcripts. An orphan drug is a medication or other medicinal product used to treat a rare disease or disorder. In cases like this, those trailing the leader hope to bring to market a new drug that can be a viable competitor to the original one. What are 4 types of drugs? Is evergreening of patents legal? So there you have it - case closed, eh? But it would also lower the revenues of biopharmaceutical companies and that, in turn, will reduce the number of new drugs produced each year.
Patents on the first synthetic insulin expired in 2014, but these newer forms are harder to copy, so the unpatented versions will go through a lengthy Food and Drug Administration approval process and cost more to make. The mission is to provide"Best On The Go"training services across those industriesTo Create, Develop, Train tomorrows Industry leaders. In the case of the cholesterol-lowering statins, Lipitor and Crestor were the fourth and fifth statins approved by the FDA. In the United States, a patent expires 20 years after its application date. However, me-too products may create competition and drive prices down. What is a novel drug? A compound that is structurally very similar to already known drugs, with without minor pharmacological differences. If all other sites open fine, then please contact the administrator of this website with the following information.
Which is an orphan drug? Most of the time follow on or me too drugs are less costly as compared to innovator molecule patented molecule. What are first in class drugs? As Larry Levitt, executive vice president for health policy at the Kaiser Family Foundation, Levitt implies that drugs that are not first-in-class — so called me-too drugs — offer little value. What is a me too product? This is legally impossible. A less active drug produces less response, and a more active drug produces more response. I'll let the authors sum things up: Overall, these results indicate that new drug development is better characterized as a race to market among drugs in a new therapeutic class, rather than a lower risk imitation of a proven breakthrough.
Why does drug development take so long? According to the Journal of Molecular Medicine, Ribose-5 phosphate isomerase deficiency, or RPI Deficinecy, is the rarest disease in the world with MRI and DNA analysis providing only one case in history. What are the four main drug actions? In pharmacology and pharmaceutics, a prototype drug is an individual drug that represents a drug class — group of medications having similar chemical structures, mechanism of action and mode of action. Orphan drugs may be defined as : Drugs that are not developed by the pharmaceutical industry for economic reasons but which respond to public health need. To be called a biosimilar drug, a biological drug must be shown to be as safe as, work as well as, and work in the same way as its reference drug. Let the Food and Drug Administration review the first me-too drugs in the usual way. This was also done in order to increase access of the public to patented drugs, by avoiding unnecessary protection to the inventors.
What drugs are structural analogs? Novel drugs are often innovative products that serve previously unmet medical needs or otherwise significantly help to advance patient care and public health. Indeed, an increasing number of physicians have stopped seeing drug representatives altogether. Look at the timing. What is the difference between biologics and biosimilars? How do drugs act in the body? In cases like this, those trailing the leader hope to bring to market a new drug that can be a viable competitor to the original one. This number includes, among other things, gifts for physicians, drug samples, market research, meals for doctors and their staffs, hotel stays, and generous salaries. The authors have covered a lot of ground, looking at first-in-class drugs approved from the early 1960s up to 2003, with later entrants in the same areas accepted up to 2007. Biologics have revolutionized the prevention, diagnosis, and treatment of cancer, autoimmune conditions, and other diseases.
