Preparation of aspirin from salicylic acid. Synthesis of Acetyl Salicylic Acid (Aspirin) Essay Example 2022-10-29

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Aspirin is a commonly used pain reliever and anti-inflammatory medication. It is also known as acetylsalicylic acid, and is derived from salicylic acid, a compound found in plants such as willow trees. The preparation of aspirin involves a chemical reaction between salicylic acid and acetic anhydride, with the addition of a small amount of sulfuric acid as a catalyst.

To prepare aspirin, the following materials and equipment are needed:

The first step in preparing aspirin is to measure out the appropriate amounts of salicylic acid and acetic anhydride. These two compounds are mixed together in a beaker, along with a small amount of sulfuric acid as a catalyst. The mixture is then stirred thoroughly with a stirring rod to ensure that the compounds are well combined.

Next, the mixture is transferred to a flask, and heated over a Bunsen burner until the reaction is complete. The temperature of the mixture should be kept at around 70-80°C, and the reaction should be allowed to continue for about an hour.

After the reaction is complete, the mixture is allowed to cool and then filtered through a piece of filter paper. The resulting solid product is aspirin, which can be collected by pressing it out of the filter paper using a glass funnel.

It is important to note that the preparation of aspirin requires careful handling of chemicals, as some of the compounds used are potentially dangerous. Proper protective equipment, such as goggles and gloves, should be worn at all times during the preparation process.

Overall, the preparation of aspirin from salicylic acid is a simple chemical reaction that can be easily carried out in a laboratory setting. The resulting product, acetylsalicylic acid, is a widely used pain reliever and anti-inflammatory medication that is effective in reducing the symptoms of various conditions such as headache, fever, and inflammation.

The reagent(s) used in the preparation of aspirin from salicylic acid is: (a) ${ SOCl }_{ 2 }$, pyridine(b) ${ (CH }_{ 3 }CO{ ) }_{ 2 }O$, ${ H }^{ + }$(C) ${ CH }_{ 3 }{ CO }_{ 2 }H$, HCl(d) ${ CH }_{ 3 }Cl$, $Al{ Cl }_{ 3 }$

preparation of aspirin from salicylic acid

Instead of the normal procedural method, the measured amounts of each substance were given. It was hard to see the figures and it was old and had scratches on the panel. . Therefore, the more salicylic acidthat contaminatesyour aspirin,the darker the color will bewithFeCl 3. Do not allow temperature to exceed 70 degrees. Prior to doing this experiment, proper safety precautions were taken and protocols were reviewed. The product will appear as a solid mass when crystallization is completed.

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Experiment_614_Synthesis of Aspirin_1_1_2

preparation of aspirin from salicylic acid

The solid is trapped by the filter, and the liquid is sucked into the flask by a vacuum through the funnel. The crystals were placed between several sheets of filter paper using a spatula and press-dried. Finally the water was poured to the paper to wet it and then the water aspirator was turned on to a maximum water flow and the solution in the beaker poured into the funnel. . To determine actual yield of acetylsalicylic acid isolated.

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Aspirin (Synthesis and Mechanism)

preparation of aspirin from salicylic acid

If you are calculating the actual and theoretical yield , be sure to note how much salicylic acid you actually measured. Human error was also taken into account Time Other problems also included time factor. . Vacuum filtration will be used to collect the solid aspirin, which will be checked for purity once again. Submit the crystalline sample in a small vial with proper labeling to your instructor FERRIC CHLORIDE TEST FOR SALICYLIC ACID Add 10 drops of aqueous 1% ferric chloride solution to a test tube containing a few crystals of the compound to be tested dissolved in 5 mL water and note the color. Salicylic acid, whose name comes from Salix, the willow family of plants, was derived from willow bark extracts.

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1: Synthesis of Aspirin (Experiment)

preparation of aspirin from salicylic acid

Objective: To illustrate the synthesis of the drug, aspirin and determine its purity by a chemical test Materials and methods: Synthesis of Aspirin A water- bath was prepared by filling half-way a 400mL beaker with water and the water heated to boiling point. Title: Preparation of Acetylsalicylic Acid Aspirin 0. Section 2: Safety Precautions and Waste Disposal Safety Precautions: Use of eye protection is recommended for all experimental procedures. This way an idea of the safety conditions and the handling of chemicals can be considered. You can use some of the filtrate to rinse the Erlenmeyer flask if necessary. . Sulphuric acid or phosphoric acid will be used as a catalyst.

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How to synthesize aspirin?

preparation of aspirin from salicylic acid

Chill for at least 10 minutes in order to obtain the maximum amount of crystalline product. These can be found under the hypothesis subheading. It is also antipyretic. . When FeCl3 is added to an aspirin sample, the purple hue changes, indicating that some salicylic acid is still present and the sample is impure.

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S11195638 CH102 Preparation of Aspirin (Acetyl salicylic acid)

preparation of aspirin from salicylic acid

Salicylic acid is ortho-hydroxybenzoic acid. Although this sounds far fetched it was still a flaw in the experiment. . The sulphuric acid in this experiment was used as a catalyst and dehydrating agent to aid the synthetization of acetylsalicylic acid. For example the reflux used in the experiment has some sort of residue contained inside it. Incomplete or competing reactions, as well as sample loss during recovery, are all plausible reasons for product yield percentages that aren't 100%.

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Preparation of Acetyl Salicylic Acid (Aspirin) Lab Report

preparation of aspirin from salicylic acid

Ask instructor to assist with thecleaning ofany spills. After that, water will be added, and the solutions will be cooled and chilled gradually. The Merck Index, which is an encyclopedia of chemicals, drugs and biologicals, lists the following information under aspirin: acetylsalicylic acid; monoclinic tablets or needle-like crystals; mp 135 °C rapid heating ; is odorless, but in moist air it is gradually hydrolyzed into salicylic and acetic acids; one gram dissolves in 300 mL of water at 25 °C, in 100 mL of water at 37 °C, in 5 mL alcohol, in 17 mL chloroform. To speed up the reaction, a small amount of strong acid is employed as a catalyst. State the function of sulphuric acid in the experiment. As a result it had to be assumed they were correct.

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CHM457 LAB REPORT 4 Preparation of Acetylsalicylic Acid (Aspirin)

preparation of aspirin from salicylic acid

In each of the test tubes, 5mL of distilled water was added and test tubes shaken to dissolve the crystals and a further 10 drops of 1% aqueous ferric chloride was also added to each test tube. Wait and observe a little longer until all of the aspirin has melted. In addition to the irritation caused by acidity, aspirin causes stomach irritation by inhibiting the production of prostaglandins, hormones responsible for slowing the production of stomach acid. The obtained product was tested for unreacted salicylic acid. . Place the contents into a beaker with around 750 ml of cool water.

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