Cystic fibrosis research paper outline. Research Paper On Cystic Fibrosis 2022-10-14
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Cystic fibrosis (CF) is a chronic, genetic disease that affects the respiratory and digestive systems. It is caused by a mutation in the gene that encodes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein, which regulates the movement of salt and water in and out of cells. As a result of the mutation, thick and sticky mucus builds up in the lungs, pancreas, and other organs, leading to a range of serious health problems, including difficulty breathing, frequent lung infections, and malnutrition.
CF is a rare disease, affecting about 30,000 people in the United States and 70,000 people worldwide. It is most common in people of Northern European ancestry, but it can affect people of any racial or ethnic background. There is currently no cure for CF, but treatments such as antibiotics, airway clearance techniques, and nutritional support can help improve quality of life and extend lifespan.
Other complications (liver disease, diabetes, infertility)
III. Diagnosis and treatment of CF
Tests and procedures used to diagnose CF (sweat test, genetic testing)
Current treatments for CF (antibiotics, airway clearance techniques, nutritional support)
Experimental treatments and potential therapies (gene therapy, CFTR modulators)
IV. The impact of CF on patients and their families
Physical and emotional challenges of living with CF
Support systems for individuals with CF and their families
Advocacy and research efforts to find a cure for CF
Recap of the main points of the essay
Reflection on the importance of ongoing research and treatment for CF
Call to action for readers to learn more about CF and support efforts to find a cure.
Cystic Fibrosis Research Paper Outline
Although exposure to air pollution in the home and workplace, genetic factors and respiratory infections also play a role in the disease. There are also some forms of complications that are usually associated with the untreated patients. The source of cystic fibrosis is a defective gene that affects the secretory glands and causes them to create mucus that is thick and sticky which eventually builds up in organs such as the lungs, pancreas, liver, sinuses, sex organs, and intestines. This is done by helping parents and children manage long-term, often-complex health problems and injuries e. The most common gastrointestinal symptom noted with cystic fibrosis are the meconium ileus, abdominal distention, intestinal obstruction, increased frequency of stools, failure to thrive despite adequate appetite , flatulence or foul-smelling flatus, steatorrhea, recurrent abdominal pain, jaundice and gastrointestinal bleeding. However, it was surprising for the researchers to note that glibenclamide, when in high concentration, promotes the differentiation of endocrine cells. This disease also effects the …show more content… Delta F508 is the most common mutation in …show more content… REPETATIVE, CHANGE INTRO It is estimated that 1 in every 3,700 births will have cystic fibrosis placing this disease the second most common life-shortening inherited disease.
Genome Cystic Fibrosis is a disease caused when the CFTR Cystic Fibrosis Transmembrane Regulator is defective and the cells do not release the right amount of chloride. There are many Current research includes studies that seek to find answers on the physical complications and behavioral aspects of CF, as well as the cost-effectiveness of new versus old treatments. An alternative therapy might be the use of a mechanical precursor that uses high frequency waves in order to pull the mucus out of the chest. CFTR modulators known as Ivacaftor VX-770 is a small molecular weight oral drug which is being produced to manage patient with the G551D mutation in one of the CFTR genes. In the United States alone, 30,000 people have cystic fibrosis and 1,000 new cases of CF are diagnosed every year.
Over time, this mucus clogs your passageways which eventually leads to infections. Using gravity, the thick mucus forces itself down thereby reducing the quantity in the chest. Lung disease is usually manifested as obstructive lung disease due to bronchiectasis. The secretions plug up tubes, ducts and airways in the lungs and pancreas. Cardiogenic pulmonary oedema is defined as the build-up of fluid in the lungs usually due to Heart failure. The throat gets a burning sensation and a severe irritation, causing a sudden, severe sore throat. Through encountering a surface containing contaminants such as feces, puts a person at risk for the later development of diseases such as c.
The sweat test is developed based on strategies whereby the ratio between the two types of sweat are analyzed using dyes. Food and Drug Administration FDA approves and oversees all clinical trials conducted in the U. In patients with the condition, the findings observed is that that CFTR gene produces some proteins that are not effective in their function. This bacterium can also be spread through contact from healthcare workers that have not followed correct cleansing routines such as but not limited to hand washing. Treatment and management once there has been an early detection of this disease, a number of interventions may be applicable to manage the condition.
While most people associate cystic fibrosis with progressive lung disease, CF impacts the respiratory, digestive, reproductive, and endocrine systems. Being a long term disease with no cure, administration of cystic fibrosis is critical and many guardians fight financially to take care of the expense of treatment and medicine required for their child. One can predict the chances of the phenotype inheriting the cystic fibrosis gene from the genotype. Causes of Pulmonary Oedema The two main causes of oedema are cardiogenic and non-cardiogenic. It has been noted in recent times that the major cause of death relating to the cystic fibrosis is the end-stage lung disease associated with it. .
This gene has been found to make a protein which is responsible for the control of the movement of salt and water in and out of our body cells. In the case of CF, many potential new drugs target certain genetic mutations, such as F508del. A defective gene causes the secretions to become thick and sticky. There are four types of sanflippo syndrome based on the defective gene that encode for the enzyme. This is just another reason why people should not smoke. It also maximizes the remaining capabilities and functions of an already disabled patient. Cystic Fibrosis: The Facts is an ideal source for people suffering from cystic fibrosis or for people who have loved ones suffering from the disease.
Although cystic fibrosis cannot be cured there are several treatment options. This finding suggests that this drug actually possesses some off-target action. People have often told me that I am hard on myself when it comes to dreams and goals. This characteristically results in disease affecting multiple organ systems, most notably the lungs and gastrointestinal tract. Strep throat generally affects the throat and tonsils and makes swallowing hard. Sticky mucus obstructs airflow in bronchioles and small bronchi Gould, 2002.