Cerebrospinal fluid (CSF) is a clear, colorless fluid that surrounds the brain and spinal cord. It plays a number of important roles in the body, including cushioning and protecting the brain and spinal cord, removing waste products from the brain, and maintaining a constant pressure around these vital organs. One of the key components of CSF is chloride, which is an electrolyte that helps to regulate the balance of fluids in the body.
Chloride is an anion, or negatively charged ion, that is formed when chlorine gains an extra electron. It is an essential component of the body's electrolyte balance, as it helps to regulate the pH of the body's fluids. Chloride is found in a number of body fluids, including blood, sweat, and urine, and it is also an important component of CSF.
In CSF, chloride plays a number of important roles. It helps to regulate the pH of the fluid, which is important for maintaining the proper function of the brain and spinal cord. Chloride also helps to remove waste products from the brain, as it is involved in the process of osmosis, which helps to filter out toxins and other unwanted substances from the brain.
Chloride levels in CSF can be measured through a test known as a CSF chloride test. This test is typically used to diagnose certain medical conditions, such as meningitis, a brain tumor, or a brain abscess. Abnormal levels of chloride in CSF can also be a sign of other health problems, such as dehydration or kidney disease.
It is important to maintain the proper balance of chloride in CSF, as an imbalance can lead to a number of health problems. For example, high levels of chloride in CSF can cause an electrolyte imbalance, which can lead to muscle weakness, fatigue, and other symptoms. Low levels of chloride in CSF can also cause problems, as it can lead to a decrease in the body's ability to remove waste products from the brain, which can lead to a buildup of toxins and other harmful substances.
Overall, chloride is an important component of CSF, and it plays a number of important roles in maintaining the health and function of the brain and spinal cord. Proper levels of chloride in CSF are essential for maintaining the body's electrolyte balance and for removing waste products from the brain.
Cerebrospinal Fluid (CSF) Tests: Normal Values
Before undergoing a CSF test, you will be asked to empty your bowels and bladder. The codes reflect our interpretation of CPT coding requirements based upon AMA guidelines published annually. CPT Codes The American Medical Association Current Procedural Terminology CPT codes published in ARUP's Laboratory Test Directory are provided for informational purposes only. CSF moves in a single outward direction from the ventricles, but multidirectionally in the subarachnoid space. CPT coding is the sole responsibility of the billing party.
Spinal Fluid Chloride: A Test 40 Years Past Its Time
Cerebrospinal Fluid in Clinical Practice. CONCLUSION: CSF chloride levels can substantiate the diagnosis of meningitis and can be indicative, supporting the etiological diagnosis. European Annals of Otorhinolaryngology, Head and Neck Diseases. In an era when tuberculous meningitis was a common CNS infection, classic teaching held that a low CSF chloride value was almost pathognomonic of this severe disease. Even though about 500mL of CSF is produced per day, it will be later on replaced every few hours. The total volume of CSF in adults ranges from 90 to 150mL, whereas 10 to 60 mL in infants.
CSF chloride levels are estimated in all the study subjects. In low blood chloride level. Hence prompt, early definite initiation of treatment could save lot of lives. It falls in the CSF in case of bacterial meningitis due to increased proteins in the CSF. Basic clinical neuroscience 2nded. Conclusion Although initially daunting, obvious patterns will become recognisable.
Significance of chloride contents in cerebrospinal fluid and plasma and their ratio in early diagnosis and differential diagnosis of central nervous system infections
As the forebrain develops, the neural cord within it becomes a ventricle, ultimately forming the lateral ventricles. Cerebrospinal Fluid CSF is a transparent liquid that surrounds and protects the brain and spinal cord. The chloride content in CSF was significantly lower in tuberculous meningitis and cryptococcal meningitis patients than in viral meningitis patients. You will not be expected to know this skill for examinations, however you may be asked to interpret some CSF results. What Do the Results Indicate? Functional Anatomy and Physiology of Domestic Animals. Therefore make sure to learn the common causes of. CSF test, in conjunction with the blood or urine test , can help evaluate your current medical condition.
A patient's CSF test values should be interpreted based on the reference value of the laboratory in which the test was done; the laboratory typically provides these values with the test result. National Institute of Neurological Disorders and Stroke. What are the other methods used to collect CSF samples? If the sample is collected in three tubes, all the tubes will be the same color. This test is not done in routine unless requested. Lymphatic Research and Biology. Textbook of medical physiology 11thed. Some representative values are listed in alphabetical order in the following table.
If the CSF test results come back normal, then it means that there is nothing abnormal found within the cerebrospinal fluid. It is also more likely that you will be asked about the more common conditions, such as bacterial and viral If the condition asked about is either kind of meningitis, it is most likely that a causative organism will be asked for. The healthcare provider will insert a spinal needle into your spinal canal, and the opening pressure reading is taken. Now the third tube will be clear or less in color. This station tests your knowledge of both the normal values of various components of CSF, and also your ability to make a differential diagnosis of a condition purely from a set of CSF results.
You will be asked to lie down, without lifting your head for an hour or more after the test. The most important of these are given in the below note that these are for adults only. Anatomy and Physiology 6thed. The chloride contents in sample of CSF and plasma of disease group and the change in ratio of the two chloride contents were observed, and the ROC curves were generated according to the results, in order to analyze the statistical significance in early diagnosis and differential diagnosis of central nervous system infections. ARUP Laboratories assumes no responsibility for billing errors due to reliance on the CPT codes published. Call us or fill out the form and we'll help in any way we can.
Start at the top and comment whether each result is normal or not. I was a junior medical student assigned to Bellevue's pediatric tuberculosis service in the mid-1940s, one of the largest of its kind in the country. The changes in various conditions are given below. Davidson's principles and practice of medicine 21sted. If any result is abnormal, it should be commented whether the result is slightly or very deranged. Still mortality is high especiallyin a developing country like ours. Retrieved 14 April 2018— via Google Books.